The establishment of the company Mostostal Puławy S.A. is associated with the construction of Zakłady Azotowe Puławy (Puławy Nitrogen Plants), the so-called Wielka Chemia (Great Chemistry). In 1964, a Branch of Warszawskie Przedsiębiorstwo Konstrukcji Stalowych i Urządzeń Przemysłowych (Warsaw Steel Construction and Industrial Equipment Enterprise) was established for the construction of technological installations at Zakłady Azotowe Puławy.
The branch in Puławy has been developing in the structures of Mostostal Warszawa S.A. for nearly 30 years. In 1994, the company transformed into a spółka z ograniczoną odpowiedzialnością [limited liability company], and in 1998 into a spółka akcyjna [joint stock company]. As a result of the purchase of the companies Mezap sp. z o.o. i Energezap sp. z o.o., in 2005 Grupa Kapitałowa Mostostal Puławy was established.
Since December 2014, Mostostal Puławy S.A has been developing as a company in a new ownership structure. The group of investors includes the Management Board of Mostostal Puławy S.A. and entrepreneurs from Puławy. The new owners focus on the dynamic development of the company and the continuation of 50 years of tradition.